The amino acids
-
arginine is highly concentrated in phagosomes as part of so-called defensins
Hexose Monophosphate shunt (aka Pentose Phosphate
Pathway)
-
utilizes pentoses which are derived from glucose. Glucose 6 Phosphate is
catalyzed to a lactone by Glucose-6-phosphate dehydrogenase aka
G6PD an enzyme.
-
produces NADPH aka reduced nicotinamide-adenine dinucleotide phosphate
-
electrons pass from NADPH to an FAD containing membrane
flavoprotein and thence to cytochrome (cytb558) which reduces molecular oxygen
to bactericidal superoxide radicals
-
thiamine pyrophosphate functions in the
utilization of pentose in the hexose monophosphate shunt in the production
of NADPH
-
riboflavin functions in the formation
of FAD and FMN
Gludocse-6 phosphate dehydrogenase G6PD deficiency-an
inborn error of metabolism by which NADPH is not
produced efficiently. NADPH is necessary to keep glutathione a stabilizing
factor in the RBC membrane. The result is a tendancy to hemolysis.